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Symbol Name ID |
Hfe
homeostatic iron regulator MGI:109191 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
Leukocytosis |
Hemophagocytosis |
Acute lymphoblastic leukemia |
T-cell acute lymphoblastic leukemias |
Myeloproliferative disorder |
Sinusitis |
Chronic sinusitis |
Lymphadenopathy |
Splenomegaly |
Hepatosplenomegaly |
Hepatitis |
Chronic hepatitis |
Viral hepatitis |
Subacute progressive viral hepatitis |
Pancreatitis |
Cutaneous abscess |
Eczematoid dermatitis |
Recurrent bacterial skin infections |
Recurrent pneumonia |
Anti-citrullinated protein antibody positivity |
Rheumatoid factor positive |
Systemic lupus erythematosus |
Asthma |
Nontuberculous mycobacterial pulmonary infection |
Recurrent Burkholderia cepacia infections |
Recurrent Haemophilus influenzae infections |
Recurrent Staphylococcus aureus infections |
Recurrent Aspergillus infections |
Recurrent respiratory infections |
Recurrent bronchopulmonary infections |
Recurrent lower respiratory tract infections |
| Disease(s) Associated with HFE | |||||||||||||||||||||||||||||||||||
| acute lymphoblastic leukemia | |||||||||||||||||||||||||||||||||||
| beta thalassemia | |||||||||||||||||||||||||||||||||||
| cystic fibrosis | |||||||||||||||||||||||||||||||||||
| hemochromatosis type 1 | |||||||||||||||||||||||||||||||||||
| hepatocellular carcinoma | |||||||||||||||||||||||||||||||||||
| multiple myeloma | |||||||||||||||||||||||||||||||||||
| myelofibrosis | |||||||||||||||||||||||||||||||||||
| polycythemia vera | |||||||||||||||||||||||||||||||||||
| porphyria cutanea tarda | |||||||||||||||||||||||||||||||||||
| rheumatoid arthritis |
| Mouse Phenotypes | increased osteoclast cell number |
decreased spleen iron level |
increased spleen iron level |
|
| Availability | Mouse Genotype | |||
| Hfetm1.1Wsr/Hfetm1.1Wsr | ||||
| Hfetm1Gfn/Hfetm1Gfn | ||||
| Hfetm2Nca/Hfetm2Nca | ||||
| Hfetm1Wsr/Hfetm1Wsr Tg(Alb1-cre)7Gsc/? (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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